(From MAD #1, credit to Stopgeek.)
This Western parody by Kurtzman and Severin features a saloon shoot-out away from prying eyes. We see sound over smoke and then sound over yellow paper. The second panel is busier and "louder" than the first, but also more fake and funny: we are reminded that these are not sounds at all, but visual substitutes for sounds. Every sound effect is written down -- gasp! -- and every onomatopoeic urge is humbled by the familiar iconography of block letters and exclamation points. Every sound effect also seeks to split and split from the yellow paper, pretend it doesn't exist.
WHIZZZZY-WHIG! Next up: Lynda Barry.